Exercise’s Impact on Cardiometabolic Function: from Extracellular Vesicles to Adipose Tissue Remodeling

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Video Summary

In summary, Dr. Mallon discussed the impact of exercise on insulin sensitivity. Specifically, his study looked at extracellular vesicles (EVs) during fasted and insulin-stimulated states in adults with obesity or metabolic syndrome. He highlighted the potential role of EVs in vascular function and insulin sensitivity, suggesting that exercise may help in reducing EVs, thus improving metabolic functions. On the other hand, Dr. Negró presented research on exercise-induced changes in inguinal white adipose tissue (IWAT) remodeling. His study revealed that exercise training led to reduction in ECM deposition, increased innervation, and refinement of the neuronal compartment in IWAT. Factors such as NHGRI-1 and the PRDM16 transcriptional complex were implicated in these changes, leading to improved vascularization and insulin sensitivity in adipose tissue.

Keywords

insulin sensitivity

exercise

extracellular vesicles

obesity

metabolic syndrome

vascular function

IWAT remodeling

ECM deposition

NHGRI-1

PRDM16