Exercise Physiology Discussion - "Lactate in Contemporary Biology: A Phoenix Risen"

Video Transcription

Video Summary

Dr. George Brooks gave a talk on the role of lactate in exercise physiology. He discussed how lactate is not just a waste product, but also functions as a fuel, a signaling molecule, and is involved in the adaptive process. Lactate shuttling and lactate oxidation were emphasized, along with the postprandial lactate shuttle, which is the movement of lactate from the gut to the liver. Dr. Brooks also highlighted the importance of lactate as a gluconeogenic precursor and its role in glucose metabolism. He mentioned that lactate is a preferred fuel over glucose in certain instances and that it can be used by various tissues in the body. Additionally, lactate was shown to have signaling properties, such as inhibiting lipolysis and stimulating brain-derived neurotrophic factor secretion in the brain. Dr. Brooks concluded by mentioning ongoing research on lactylation, the process of adding lactate to various molecules, such as histones and amino acids, and its potential role in biology. Overall, his talk emphasized the multifaceted functions of lactate and how our understanding of lactate has evolved over time.

Keywords

lactate

exercise physiology

fuel

signaling molecule

lactate shuttling

gluconeogenic precursor

lactylation